Current Issue
Volume 31 Issue 4: August 22, 2008
Next issue: September 5, 2008
Included in this issue:
• Telomere attrition-induced chromosome fusions
• CCAR1 recruits Mediator to promoters via nuclear receptors or p53
• Biochemical reconstitution of V(D)J recombination
• AID interaction with the splicing factor CTNNBL1
• UbcH10 controls APC/C activation
• Review: Nonhistone lysine acetylation
Featured Article
The Featured Article is freely available to all readers
Wang et al. Chromosome Fusions following Telomere Loss Are Mediated by Single-Strand Annealing
Progressive telomere shortening eventually results in chromosome fusions and genome instability as the cell's ability to distinguish chromosome ends from DNA double-strand breaks is compromised. In fission yeast, such events frequently produce stable survivors with all circular chromosomes. To shed light on the repair pathways that mediate chromosome end fusions and generate circular chromosomes, we have examined a diverse array of DNA repair factors. We show that telomere attrition-induced chromosome fusions are dependent on the fission yeast homologs of Rad52, the ERCC1/XPF endonuclease, the single-stranded DNA-binding protein RPA, and the Srs2 and Werner/Bloom helicases, but not Ku and ligase 4. Consistent with a recombinational mechanism of single-strand annealing, cloned junctions map to four of five homology regions in subtelomeric DNA. A comparison with telomere uncapping caused by the absence of the double-stranded telomere-binding protein Taz1 demonstrates that the circumstances and cause of telomere dysfunction profoundly affect which DNA repair pathway is engaged.
Featured Topic
Ubiquitin and ubiquitin-like modifications play important roles in regulating protein turnover and signal transduction. The following selection of articles highlights some recent advances in our understanding of the diverse biological processes these modifications are involved in and of the mechanisms by which these modifications are targeted to their substrates.
Cdc20: A WD40 Activator for a Cell Cycle Degradation Machine *FREE REVIEW*
Hongtao Yu
The Age of Crosstalk: Phosphorylation, Ubiquitination, and Beyond *FREE PERSPECTIVE*
Tony Hunter
Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1
Maria Enquist-Newman, Matt Sullivan, and David O. Morgan
cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination
Mathieu J.M. Bertrand, Snezana Milutinovic, Kathleen M. Dickson, Wai Chi Ho, Alain Boudreault, Jon Durkin, John W. Gillard, James B. Jaquith, Stephen J. Morris, and Philip A. Barker
The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation
Xinsong Xu, Antonio Sarikas, Dora C. Dias-Santagata, Georgia Dolios, Pascal J. Lafontant, Shih-Chong Tsai, Wuqiang Zhu, Hidehiro Nakajima, Hisako O. Nakajima, Loren J. Field, Rong Wang, and Zhen-Qiang Pan
CHIP-Mediated Degradation and DNA Damage-Dependent Stabilization Regulate Base Excision Repair Proteins
Jason L. Parsons, Phillip S. Tait, David Finch, Irina I. Dianova, Sarah L. Allinson, and Grigory L. Dianov
Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25
Erik Meulmeester, Marion Kunze, He Hsuan Hsiao, Henning Urlaub, and Frauke Melchior
SUMO-2/3 Modification and Binding Regulate the Association of CENP-E with Kinetochores and Progression through Mitosis
Xiang-Dong Zhang, Jacqueline Goeres, Hong Zhang, Tim J. Yen, Andrew C.G. Porter, and Michael J. Matunis
Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation
Thimo Kurz, Yang-Chieh Chou, Andrew R. Willems, Nathalie Meyer-Schaller, Marie-Lyn Hecht, Mike Tyers, Matthias Peter, and Frank Sicheri
Top 20 Articles
These are the Top 20 Papers by download from the Molecular Cell web site for the last 30 days. You can see the summaries if you are registered, or full text and PDFs if you have subscribed.
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