26 December, 2008
Volume 32, Issue 6
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Volume 32, Issue 6
On the cover: The symmetric core of the nuclear pore complex (NPC) can be envisioned as a series of four concentric porous cylinders. A slice through the nuclear envelope is shown, where only the pore membrane cylinder (dark green) and the coat cylinder of the NPC in the foreground are displayed for clarity. In this issue, Debler et al. (p. 815) report three structures of a key component of the NPC coat cylinder. The atomic coordinates of Sec13•Nup145C and Seh1•Nup85 were used to generate the molecular surfaces of the vertical poles (yellow) in the coat cylinder. Horizontal links mediated by Nup120 (light green), as well as by Nup84 and Nup133 (not shown), would give rise to a fence-like NPC coat. Artwork by Joseph Alexander, Erik W. Debler, and André Hoelz.
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Announcements
Molecular Cell congratulates Robert Tjian, member of its Editorial Board, for his election as the new President of the Howard Hughes Medical Institute.
Molecular Cell congratulates Victor Ambros, David Baulcombe, and Gary Ruvkun for the 2008 Albert Lasker Basic Medical Research Award recognizing their pioneering efforts in discovering small regulatory RNAs.
Molecular Cell congratulates Osamu Shimomura, Martin Chalfie, and Roger Y. Tsien for the 2008 Nobel Prize in Chemistry honoring their work on Green Fluorescent Protein, GFP.
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Molecular Mechanisms @ Cell Press
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Jeremy E. Wilusz, Susan M. Freier, and David L. Spector
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Zuopeng Wu, Xinying Jia, Laura de la Cruz, Xun-Cheng Su, Bruz Marzolf, Pamela Troisch, Daniel Zak, Adam Hamilton, Belinda Whittle, Di Yu, Daniel Sheahan, Edward Bertram, Alan Aderem, Gottfried Otting, Christopher C. Goodnow, and Gerard F. Hoyne
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Manfred Schmid and Torben Heick Jensen
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Volume 32 Issue 6: December 24, 2008
Cotranscriptional Recruitment of the mRNA Export Factor Yra1 by Direct Interaction with the 3’ End Processing Factor Pcf11
Sara Ann Johnson, Gabrielle Cubberley, and David L. Bentley
Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase II
Thomas S. Ream, Jeremy R. Haag, Andrzej T. Wierzbicki, Carrie D. Nicora, Angela Norbeck, Jian-Kang Zhu, Gretchen Hagen, Thomas J. Guilfoyle, Ljiljana Paša-Tolić, and Craig S. Pikaard
*FREE REVIEW*
David M. Lonard, Bert W. O'Malley *FREE TiBS REVIEW*
Miriam Calao, Arsène Burny, Vincent Quivy, Ann Dekoninck, Carine Van Lint Maria Divina E. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu, Robert Tjian Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, Eric Metzger, Shun Sawatsubashi, Eriko Suzuki, Xavier Le Guezennec, Hendrik G. Stunnenberg, Aleksey Krasnov, et al. Xiao-Yong Zhang, Maya Varthi, Stephen M. Sykes, Charles Phillips, Claude Warzecha, Wenting Zhu, Anastasia Wyce, Alan W. Thorne, Shelley L. Berger, Steven B. McMahon Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan et al. Andrea V. Gómez, Danny Galleguillos, Juan Cristóbal Maass, Elena Battaglioli, Manuel Kukuljan, María Estela Andrés Jeong Hoon Kim, Catherine K. Yang, Kyu Heo, Robert G. Roeder, Woojin An, Michael R. Stallcup Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A. Ohgi, David W. Rose, Christopher K. Glass, Michael G. Rosenfeld Ping Yi, Qin Feng, Larbi Amazit, David M. Lonard, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley
Current Issue
Volume 32 Issue 6: December 24, 2008
Next issue: January 15, 2009
Included in this issue:
Monoubiquitination of FANCD2 by FANCL, FANCI, and Ube2t
NusB and ribosomal protein S10 in bacterial antitermination
sRNA interactions with mRNA coding regions inhibit bacterial translation
Oxygen-dependent chemical inhibitors of HIF-2a translation
N-glycan binding of Yos9p in ERAD substrate recognition
Identification of yeast transcription factor motifs
NusB and ribosomal protein S10 in bacterial antitermination
sRNA interactions with mRNA coding regions inhibit bacterial translation
Oxygen-dependent chemical inhibitors of HIF-2a translation
N-glycan binding of Yos9p in ERAD substrate recognition
Identification of yeast transcription factor motifs
Click here for the complete Table of Contents.
Immediate Early Publication
Cotranscriptional Recruitment of the mRNA Export Factor Yra1 by Direct Interaction with the 3’ End Processing Factor Pcf11
Sara Ann Johnson, Gabrielle Cubberley, and David L. Bentley
Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase II
Thomas S. Ream, Jeremy R. Haag, Andrzej T. Wierzbicki, Carrie D. Nicora, Angela Norbeck, Jian-Kang Zhu, Gretchen Hagen, Thomas J. Guilfoyle, Ljiljana Paša-Tolić, and Craig S. Pikaard
Featured Articles
The Featured Articles are freely available to all readers
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There is more than one way for cells to die by apoptosis. Lapi et al. report that YAP/p73 activates PML transcription. PML, in turn, SUMOylates and stabilizes YAP. Since p73/YAP and PML promote apoptosis, these findings define an alternative apoptotic pathway that may occur in the absence of p53. |
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Translesion synthesis (TLS) DNA polymerases rescue stalled replication by copying DNA across damaged bases; however, since they are error prone, TLS polymerases must be regulated. Kim and Michael report that DNA pol eta is regulated by the SUMO and ubiquitin pathways to restrict its activity to damaged DNA. |
Featured Topic
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Coregulators of transcription, coactivators and corepressors, are often found in multiprotein complexes that assist in the communication between transcription factors and RNA polymerase II. The following selection of articles and FREE Reviews samples some of the interesting mechanisms by which coregulators work to regulate the activities of sequence-specific transcription factors. |
David M. Lonard, Bert W. O'Malley *FREE TiBS REVIEW*
Miriam Calao, Arsène Burny, Vincent Quivy, Ann Dekoninck, Carine Van Lint Maria Divina E. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu, Robert Tjian Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, Eric Metzger, Shun Sawatsubashi, Eriko Suzuki, Xavier Le Guezennec, Hendrik G. Stunnenberg, Aleksey Krasnov, et al. Xiao-Yong Zhang, Maya Varthi, Stephen M. Sykes, Charles Phillips, Claude Warzecha, Wenting Zhu, Anastasia Wyce, Alan W. Thorne, Shelley L. Berger, Steven B. McMahon Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan et al. Andrea V. Gómez, Danny Galleguillos, Juan Cristóbal Maass, Elena Battaglioli, Manuel Kukuljan, María Estela Andrés Jeong Hoon Kim, Catherine K. Yang, Kyu Heo, Robert G. Roeder, Woojin An, Michael R. Stallcup Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A. Ohgi, David W. Rose, Christopher K. Glass, Michael G. Rosenfeld Ping Yi, Qin Feng, Larbi Amazit, David M. Lonard, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley
